2000
서울대학교 학사
2006
서울대학교 박사(대학원 화학부, 생화학)
2006.03-2007.09
서울대학교 박사후연구원
2007.03-2007.08
한양대학교 시간강사
2007.10-2010.08
University of Utah 박사후연구원
2010.09-현재
서울대학교 바이오시스템·소재학부 교수
수행 연구과제
생체고분자 기반 지능성 유전자 전달체 개발 (지원기관 : 서울대)
학술논문
P.-H. Kim, T.-i. Kim, J. W. Yockman, S. W. Kim, C.-O. Yun, The effect of surface modification of adenovirus with an arginine-grafted bioreducible polymer on transduction efficiency and immunogenicity in cancer gene therapy, Biomaterials, 2010, 31, 1865-1874
T.-i. Kim, M. Lee, S. W. Kim, A Guanidinylated Bioreducible Polymer with High Nuclear Localization Ability for Gene Delivery Systems, Biomaterials, 2010, 31, 1798-1804.
Mei Ou, T.-i. Kim, J. W. Yockman, B. A. Borden, D. A. Bull, S. W. Kim, Polymer Transfected Primary Myoblasts Mediated Efficient Gene Expression and Angiogenic Proliferation, Journal of Controlled Release, 2010, 142, 61-69.
T.-i. Kim, C. Z. Bai, K. Nam, J.-s. Park, Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems, Journal of Controlled Release, 2009, 136, 132-139.
S. H. Kim, J. H. Jeong, T.-i. Kim, S. W. Kim, D. A. Bull, VEGF siRNA Delivery System Using Arginine-Grafted Bioreducible Poly(disulfideamine), Molecular Pharmaceutics, 2009, 6, 718-726.
H. A. Kim, S. Lee, J.-H. Park, S. Lee, B.-W. Lee, S. H. Ihm, T.-i. Kim, S. W. Kim, K. S. Ko, M. Lee, Enhanced protection of Ins-1β cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linkedexendin-4, Journal of Drug Targeting, 2009, 17, 242-248.
T.-i. Kim, M. Ou, M. Lee, S. W. Kim, Arginine-grafted bioreducible poly(disulfide amine) for genedelivery systems, Biomaterials, 2009, 30, 658-664.
T.-i. Kim, C. Z. Bai, J.-s. Park, Synthesis and Characterization of a Hydroxylated Dendrimeric Gene Delivery Carrier, Bulletin of The Korean Chemical Society, 2007, 28, 1317-1321.
T.-i. Kim, J.-u. Baek, C. Z. Bai, J.-s. Park, Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier, Biomaterials, 2007, 28, 2061-2067.
T.-i. Kim, J.-u. Baek, J. K. Yoon, J. S. Choi, K. Kim, J.-s. Park, Synthesis and Characterization of a Novel Arginine-grafted Dendritic Block Copolymer for Gene Delivery and Study of Its Cellular Uptake Pathway Leading to Transfection, Bioconjugate Chemistry, 2007, 18, 309-317.
T.-i. Kim, J.-u. Baek, C. Z. Bai, J.-s. Park, Synthesis of Novel Poly(amido ethylenimine) (PAMEIM) Dendrimer and Its Self-assembly with Plasmid DNA, Bulletin of The Korean Chemical Society, 2006, 27, 1894-1896.
T.-i. Kim, H. J. Seo, J. S. Choi, J. K. Yoon, J.-u. Baek, K. Kim, J.-S. Park, Synthesis of Biodegradable Cross-Linked Poly(β-amino ester) for Gene Delivery and Its Modification, Inducing Enhanced Transfection Efficiency and Stepwise Degradation, Bioconjugate Chemistry, 2005, 16, 1140-1148.
T.-i. Kim, H. J. Seo, J.-u. Baek, J.-H. Park, J.-S. Park, Synthesis of Novel Biodegradable Quaternary Amine-based Cross-linked Poly(β-amino ester) and Its Self-assembly/disassembly with Plasmid DNA, Bulletin of The Korean Chemical Society, 2005, 26, 175-177.
T.-i. Kim, H. J. Seo, J. S. Choi, H.-S. Jang, J.-u. Baek, K. Kim, J.-S. Park, PAMAM-PEG-PAMAM: Novel Triblock Copolymer as a Biocompatible and Efficient Gene Delivery Carrier, Biomacromolecules, 2004, 5, 2487-2492.
J. H. Lee, Y.-b. Lim, J. S. Choi, Y. Lee, T.-i. Kim, H. J. Kim, J. K. Yoon, K. Kim, J.-s. Park, Polyplexes Assembled with Internally Quaternized PAMAM-OH Dendrimer and Plasmid DNA Have a Neutral Surface and Gene Delivery Potency, Bioconjugate Chemistry, 2003, 14, 1214-1221.
T.-i. Kim, H.-s. Jang, D. K. Joo, J. S. Choi, J.-S. Park, Synthesis of Diblock Copolymer, Methoxypoly(ethylene glycol)-block-Polyamidoamine Dendrimer and Its Generation-dependent Self-Assembly with Plasmid DNA, Bulletin of The Korean Chemical Society, 2003, 24, 123-125.
Y.-b. Lim,T.-i. Kim, J. W. Lee, S.-m. Kim, H.-J. Kim, K. Kim, J.-s. Park, Self-Assembled Ternary Complex of Cationic Dendrimer, Cucurbituril, and DNA : Noncovalent Strategy in Developing a Gene Delivery Carrier, Bioconjugate Chemistry, 2002, 13, 1181-1185.
학술대회발표
T.-i. Kim, M. Lee, S. W. Kim, “Efficient GLP-1 Gene Delivery Using Arginine-grafted Bioreducible Polymer and Two-step Tran
T.-i. Kim, M. Lee, S. W. Kim, “Guanidinylated Bioreducible Polymer with High Nuclear Localization Ability for Gene Delivery Systems”, 2009 American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Los Angeles, California, 2009. 11. 8 ~ 12.
T.-i. Kim, M. Lee, S. W. Kim, “Guanidinylated Bioreducible Polymer for Gene Delivery Systems”, The 14th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, USA, 2009. 2. 15 ~18.
T.-i. Kim, M. Ou, M. Lee, S. W. Kim, “Arginine-grafted Bioreducible Poly(disulfide amine) for Efficient Gene Delivery Systems”, The 35th Annual Meeting & Exposition of the controlled Release Society, New York City, New York U.S.A. 2008. 7. 12 ~ 16.
T.-i. Kim, Y.-b. Lim, S.-m. Kim, J.-s. Park, “Self-Assembled Ternary Complex of Cationic Dendrimer, Cucurbituril, and DNA : Noncovalent Strategy in Developing a Gene Delivery Carrier”, The 5th CMC-Kyushu Chemistry Symposium, Seoul, 2003. 5. 9.
T.-i. Kim, Y.-b. Lim, S.-M. Kim, J.-H. Lee, J.-S. Park, “Development of Safe and Efficient Gene Delivery Carriers by Using Biodegradable Cationic Polymers”, The American Society of Gene Therapy’s 5th Annual Meeting, Boston, USA, 2002. 6. 4 ~ 11.
T.-i. Kim, Y.-b. Lim, S.-M. Kim, J.-S. Park, “Biodegradable Cationic Hyperbranched Polymer as an Efficient and Non-toxic Gene Delivery Carrier” The 6th US-Japan Symposium on Drug Delivery Systems, Hawaii, USA, 2001. 12. 16 ~ 21.
특허출원
“Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery systems” (Pending, Publication number : US 2009/0233365 A1, 2009. 2. 12)
“세포내 물질전달용 PAMAM 유도체 및 이를 이용한 세포내 원하는 물질의 전달방법 (PAMAM Derivatives for delivery of materials into cells and method for transferring desired materials into cells using the derivatives)” (등록번호 : 10-0667171-0000, 2007. 1. 4)
